Robust calibration and variance stabilization with VSN
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منابع مشابه
DATA MINING cDNA MICROARRAY EXPERIMENT WITH A GEE APPROACH
The use of microarray technology provides access to the simultaneous expression of thousands of genes and is revolutionizing the scientific community of functional genomics. This thesis investigates a cDNA microarray experiment with the goal of discovering differentially expressed genes across several factors. The analysis first ”normalizes” the data through the VSN package which is a robust ca...
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where fit is an object of class vsn that contains the fitted calibration and transformation parameters, and the method predict applies the fit to the data. The two-step protocol is useful when you want to fit the parameters on a subset of the data, e. g. a set of control or spike-in features, and then apply the model to the complete set of data (see Section 7 for details). Furthermore, it allow...
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